Marie Nyswander died in 1986. She’d achieved almost everything she set out to, but she wanted more: even better medications than methadone, fewer regulations, and the holy grail—a cure for addiction. Addiction science has come a long way since Marie’s time, and it turns out, a lot of the field’s earlier assumptions were probably wrong. Neuroscientist Kent Berridge explains why wanting something isn’t the same as liking it. But a cure is still out of our reach